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(tmp)<sub>2</sub>Zn⋅2 MgCl<sub>2</sub>⋅2 LiCl: A Chemoselective Base for the Directed Zincation of Sensitive Arenes and Heteroarenes
275
Citations
62
References
2007
Year
Inorganic ChemistryChemical EngineeringDirected ZincationSensitive ArenesEngineeringHeterocyclicCyano FunctionsOrganic ChemistryMgcl2⋅2 LiclOrganometallic CatalysisChemistryChemoselective BaseInorganic SynthesisBiomolecular EngineeringPositive ZincingInorganic Compound
Positive zincing: A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF by direct zincation using (tmp)2Zn⋅2 MgCl2⋅2 LiCl (1), an exceptionally active base. Ester and cyano functions as well as aldehydes and nitro groups are tolerated. dba=dibenzylideneacetone, tmp=2,2,6,6-tetramethylpiperidide.
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