Inverse changes in fetal insulin‐like growth factor (IGF)‐1 and IGF binding protein‐1 in association with higher birth weight in maternal diabetes

Abstract

Maternal diabetes results in inverse changes of circulating fetal IGF-1 and IGFBP-1 at birth. A decrease in circulating IGFBP-1 and to a lesser extent an increase in circulating IGF-1 may present an important mechanism that contributes to increased birth weight in diabetic pregnancies.