A Water-soluble Benzodiazepine, RO 21–3981, for Induction of Anesthesia

Abstract

Diazepam, a benzodiazepine, is widely used to produce basal narcosis prior to anesthesia because of its effectiveness and lack of cardiorespiratory side effects. The venous irritation or occasional phlebitis related to its insolubility in water is a distinct drawback.1–3 Dilution of diazepam and pri