The inflammatory response to injected microcrystalline monosodium urate in normal, hyperuricemic, gouty and uremic subjects

Abstract

Abstract Microcrystalline sodium urate was injected intradermally and subcutaneously in 15 normal subjects, 12 hyperuricemic subjects without gout, 14 patients with gout and 6 uremic subjects, and the magnitude of the inflammatory response was determined. The skin reactivity was markedly diminished in 4 of the 6 uremic patients. The range of skin reactivity was significantly greater in gouty patients than in normal or hyperuricemic subjects, but there was no significant difference in the mean inflammatory response between these groups of subjects.