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Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog

Combinatorial ChemistryBioorganic ChemistryBiochemistrySmall-molecule BinderNatural SciencesMedicineAminoalcohol-derived MacrocyclesChemical BiologyPharmacologySonic HedgehogSmall MoleculesDrug DiscoveryNatural Product Synthesis