Development of a Practical, Safe, and High-Yielding Process for the Preparation of Enantiomerically Pure <i>trans</i>-Cyclopropane Carboxylic Acid

Abstract

A practical, safe, and high-yielding process for the cyclopropanation of a chiral epoxide has been developed using the inexpensive and nonhazardous reagents triethylphosphonoacetate and sodium tert-butoxide.