Pristane-induced arthritis in mice: V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire

Abstract

The data support the hypothesis that PIA is a T cell-mediated disease. While pristane causes a polyclonal T cell expansion that gives rise to lymphadenopathy, the development of arthritis in susceptible strains of mice occurs due to the preservation of specific T cell subsets with the capacity to infiltrate synovial joints.