A distinct coagulopathy associated with Interleukin‐2 therapy

Abstract

Summary We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin‐2 (IL‐2). A 43% prolongation of the PTT (P<0.001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL‐2 treatment in comparison to pretreatment values. These parameters normalized within 2–3 d following IL‐2 administration. The PT, factors V. VII, VIII, fibrinogen and D‐dimer levels were unchanged with IL‐2 treatment. This pattern of coagulopathy has not previously been reported.