A selective, high affinity 5-HT_2Breceptor antagonist inhibits visceral hypersensitivity in rats

Abstract

These results suggest that 5-HT(2B)receptors are involved in signaling from the colon in rats in which there is visceral hypersensitivity and that a selective 5-HT(2B)receptor antagonist could have therapeutic potential for the treatment of gut disorders characterized by visceral hypersensitivity.