Targeting Estrogen Receptor-α Reduces Adrenocortical Cancer (ACC) Cell Growth<i>in Vitro</i>and<i>in Vivo</i>: Potential Therapeutic Role of Selective Estrogen Receptor Modulators (SERMs) for ACC Treatment

Abstract

These findings establish a critical role for ERα in E2- and IGF-II-dependent ACC proliferation and provide a rationale for targeting ERα to control the proliferation of ACC.