Rationale and Design of the GISSI Heart Failure Trial: A Large Trial to Assess the Effects of n-3 Polyunsaturated Fatty Acids and Rosuvastatin in Symptomatic Congestive Heart Failure

Abstract

The GISSI-HF project, with its protocol articulated into two independent randomization schemes, has the aim and the power to verify the hypothesis that n-3 polyunsaturated fatty acids and rosuvastatin can favorably modify the prognosis of patients with symptomatic heart failure.