Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes

Abstract

Aims/hypothesis: Increased expression and activity of the lipogenic pathways in adipose tissue may contribute to the development of obesity. As a central enzyme in lipogenesis, fatty acid synthase (FASN) was identified as a candidate gene for determining body fat. Our hypothesis is that increased FASN activity/expression links metabolic alterations of caloric excess, including hyperinsulinemia, dyslipidemia and altered adipokine profile to increased body fat mass.