The Liver Toxicity Knowledge Base: A Systems Approach to a Complex End Point

Abstract

Drug-induced liver injury (DILI) is a major concern in public health management, drug development, and regulatory implementation. The Liver Toxicity Knowledge Base (LTKB) was developed with the specific aim of enhancing our understanding of DILI. It seeks to achieve improvement in DILI prediction through integrated analysis of diverse sources of drug-elicited data. The project has also produced a centralized resource of data as well as predictive models that will be useful for research and drug regulation.