DIFFERENTIAL INHIBITORY EFFECTS OF INTRAVENOUS IMMUNOGLOBULIN PREPARATIONS ON HLA-ALLOANTIBODIES IN VITRO 1

Abstract

Our data suggest that the immunomodulatory capacity is largely caused by the IgM/IgA fraction of IVIG when analyzed by lymphocytotoxicity. The different effect on ELISA versus complement-dependent cytotoxicity testing suggests that interactions of IVIG with complement rather than anti-idiotypic antibodies may contribute to the inhibitory effects of IVIG in vitro.