Annals of Otology Rhinology & Laryngology · 1999 · 73 citations · 14 references
MedicinePlastic SurgerySurgeryMicrosurgeryMicrovascular ReconstructionReconstructive SurgeryFacial Plastic SurgeryFlap ReconstructionFlap SalvageFlap SurgeryFree Flap ReconstructionSkin GraftingComplication Rate AnalysisFacial Skin ReconstructionFlapsLocal Tissue FlapsMusculocutaneous FlapsPreoperative Smoking CessationSkin Flap NecrosisSkin Flaps
This study was undertaken to determine whether smokers have a higher risk of complications after reconstruction of facial skin defects. Ninety-one patients with facial skin defects reconstructed with local flaps were reviewed retrospectively. Thirty-eight (42%) were active smokers, 12 (13%) had not smoked for at least 1 year prior to surgery, and the rest were nonsmokers. Complications occurred in 23 patients (25%; 37% in smokers, 17% in ex-smokers, and 17% in nonsmokers; p < .03). All full-thickness skin losses and all cellulitis occurred in active smokers. We conclude that active smokers are at a higher risk for complications in facial skin flap surgery. That ex-smokers had a complication rate similar to that of nonsmokers suggests that part of smoking's adverse effect on skin flaps may be an acute phenomenon, and that smoking cessation for shorter (<1 year) periods of time before surgery may have a beneficial effect.
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Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages
David R. Knighton, Thomas K. Hunt, Heinz Scheuenstuhl et al. · Science · 1983 · 687 citations
Cigarette Smoking Decreases Tissue Oxygen
J. Arthur Jensen · Archives of Surgery · 1991 · 516 citations
David R. Knighton · Archives of Surgery · 1984 · 280 citations