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Stereoselective Concise Total Synthesis of Leodomycin C and D
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2011
Year
Available PropyleneBioorganic ChemistryEngineeringLeodomycin CNatural SciencesOrganic ChemistryStereoselective SynthesisChemistryNatural Product SynthesisSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringKey Steps
Stereoselective concise total synthesis of leodomycin C and D from commercially available propylene oxide using Jacobsen's hydrolytic kinetic resolution (HKR), base-promoted alkyne zipper reaction, TPP-promoted enyne ester (ynoate) to diene ester (dienoate) isomerization, and (R)-(+)-2-methyl-CBS-oxazaborolidine reduction as key steps is reported.