Cyclic AMP Effects on Antibody Formation and Their Similarities to Hormone-Mediated Events

Abstract

Cyclic AMP enhances antibody formation in vivo and in vitro as judged by tests in which sheep red blood cells served as antigen and the effects were measured by determining the early rate of increases in the number of antibody-forming spleen cells of CFW mice. Furthermore, theophylline, a known stabilizer of cAMP, was found to enhance the stimulatory effects of poly A:U on antibody formation. These observations form the basis for a discussion of apparent parallels between immunological events and known events in hormone-controlled activations of cells.