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Her-2/<i>neu</i> Overexpression and Amplification in Uterine Papillary Serous Carcinoma

DOIFull Paper Access

223

Citations

47

References

2004

Year

Brian M. Slomovitz, Russell R. Broaddus, Thomas W. Burke, Nour Sneige, Pamela T. Soliman, Weiguo Wu, Charlotte C. Sun, Mark F. Munsell, David M. Gershenson, Karen H. Lu
Journal of Clinical Oncology

Abstract

Positive IHC overexpression of Her-2/neu was seen in 18% of UPSCs but was rarely correlated with Her-2/neu gene amplification. Overexpression of Her-2/neu was associated with a worse overall prognosis. The use of trastuzumab (Herceptin; Genentech, South San Francisco, CA) in women with UPSC should be further evaluated in a clinical trial setting.

References

YearCitations

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