A study of high‐dose oral silybin‐phytosome followed by prostatectomy in patients with localized prostate cancer

Abstract

High-dose oral silybin-phytosome achieves high blood concentrations transiently, but low levels of silibinin are seen in prostate tissue. Silibinin's lack of tissue penetration may be explained by its short half-life, the brief duration of therapy in this study or an active process removing silibinin from the prostate.