Wheat Bran Decreases Aberrant Crypt Foci, Preserves Normal Proliferation, and Increases Intraluminal Butyrate Levels in Experimental Colon Cancer

Abstract

Wheat bran increased apoptosis and controlled proliferation during tumor initiation and resulted in decreased ACF. Wheat bran's antineoplastic effects occurred early after carcinogen exposure, and were associated with increased fecal butyrate levels.