Comparative Study of the Development of Diabetes Mellitus in Patients Taking Risperidone and Olanzapine

Abstract

Olanzapine was associated with a 37% (HR 1.37) increased risk of development of diabetes compared with risperidone in a VA population, even after adjusting for other factors associated with the development of diabetes and temporal exposure to study drug. Because of limitations associated with database research, prospective studies should be conducted to corroborate these findings.