Identifying an Appropriate Animal Model for the Nasolacrimal Drainage System

Abstract

Literature review demonstrates a great deal of similarity in the anatomy and histology of the nasolacrimal drainage systems of 12 mammalian species. Although a common ophthalmic research animal, the rat model has significant histologic differences that prevent its use for comparison with the human lacrimal excretory system. Current literature suggests that despite anatomical variation, the rabbit animal model could potentially be used for further characterization of the nasolacrimal drainage system because it pertains to clinical applications in human patients. Preliminary light microscopy suggests that the cynomolgus monkey may be a superior model for nasolacrimal drainage research, but further studies are required.