Rhodium(III)-Catalyzed Direct Regioselective Synthesis of 7-Substituted Indoles

Abstract

An efficient, atom-economic one-pot method was developed for the preparation of 7-substituted indoles via rhodium(III)-catalyzed oxidative cross-coupling. Regioselective olefination of indoline derivatives followed by one-pot subsequent oxidation provided the desired products in good to excellent yields.