Study of Circulating MicroRNA-125b Levels in Serum Exosomes in Advanced Melanoma

Abstract

Exosomes can provide a suitable material to measure circulating miRNA in melanoma, and miR-16 can be used as an endogenous normalizer. Lower levels of miR-125b in exosomes obtained from serum are associated with advanced melanoma disease, probably reflecting the tumoral cell dysregulation.