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Synthesis and Analgesic Activity of Some Deaza Derivatives of Anpirtoline
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1999
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Medicinal ChemistryPharmaceutical ChemistryDerivative (Chemistry)BiochemistryActive IngredientMedicineNatural SciencesMechanism Of ActionDeaza DerivativesPharmacological AgentPharmacotherapyPharmacologyReceptor Binding ProfilesNew Deaza DerivativesDrug DiscoveryAcetic Acid
New deaza derivatives of anpirtoline have been synthesized by three different methods. Their receptor binding profiles (5-HT1A, 5-HT1B) and analgesic activity (hot plate, acetic acid induced writhing) have been studied.