Two Haemoglobins Q, α74 (EF3) and α75 (EF4) Aspartic Acid→Histidine

Abstract

S ummary Six samples of Haemoglobin Q were examined, three from Iran, two from Thailand, and one from California (Chinese). They all yielded identical fingerprints. The substitution was found to be α74 or 75 aspartic acid→histidine in five of the samples. In one from Thailand ‘sequencing’ established the mutation to be at position α74 (EF3), and in one from Iran it was at position α75 (EF4). It is suggested that the gene for the α‐chain of the South East Asian haemoglobin is linked with one for α thalassaemia.