Science · 1968 · 82 citations · 13 references
Life SciencesNeurobiologyNeuroscienceBehavioral NeuroscienceNeurochemistryNeurophysiologyAddiction NeurobiologyAlcohol MetabolismAlcohol PharmacologyAlcohol Use DisorderAlcohol WithdrawalChronic Alcohol ToxicityAlcohol Dehydrogenase InhibitionMicrosomal Ethanol-oxidizing SystemNeuroadaptation To AlcoholNeuroadaptive Responses To AlcoholNeurobiology Of Alcohol WithdrawalWithdrawal Physiology
Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural disorders associated with chronic alcohol ingestion or withdrawal.
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