Haemophilia · 2004 · 17 citations · 7 references
Life SciencesInfectious DiseasesMicrobiologyMedical MicrobiologyMolecular VirologyVirologyViral InfectionsViral Protein ProcessingVirus PurificationVirus RemovalWest Nile Virus InfectionFactor Viii PhysiologyFactor Viii ReplacementSolvent-detergent InactivationViral InactivationVirus Inactivation MechanismsVirus ProductionVirus RecoveryWest Nile Virus Disease
West Nile Virus (WNV) was immediately and completely inactivated to below assay detection limits upon addition of solvent/detergent (S/D) to intermediate process pools of second and third generation B-domain deleted recombinant Factor VIII (BDDrFVIII; ReFacto, Wyeth, Cambridge, MA, USA). We verify that the S/D step provides robust enveloped virus inactivation (>5 log(10)) and functions as a WNV barrier.
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Inactivation of viruses in labile blood derivatives. II. Physical methods
Bernard Horowitz, Michael E. Wiebe, A. Lippin et al. · Transfusion · 1985 · 56 citations