Makaluvamine P, a New Cytotoxic Pyrroloiminoquinone from <i>Zyzzya </i>cf. <i>fuliginosa</i>

Abstract

A new pyrroloiminoquinone alkaloid (1) belonging to the makaluvamine family has been isolated from the sponge Zyzzya cf. fuliginosa collected in the waters off the Vanuatu Islands. The compound, designated makulavamine P, was characterized on the basis of its spectral data and displayed cytoxicity in the microM range on KB cells and antioxidant activity.