Doxorubicin pharmacokinetics following a single‐dose infusion to sulphur‐crested cockatoos (<i>Cacatua galerita</i>)

Abstract

Doxorubicin infusion in sulphur-crested cockatoos produced mild, transient inappetence. The volume of distribution per kilogram and terminal half-life were considerably smaller, but the clearance per kilogram was similar to or larger than reported in the dog, rat and humans. Traces of doxorubicinol, a metabolite of doxorubicin, were detected in the plasma.