Evaluation of antimicrobial and antiplatelet aggregation effects of<i>Solidago chilensis</i>Meyen

Abstract

Solidago species have been used in popular medicine for the treatment of several inflammatory conditions. The aim of this study is to evaluate both the antimicrobial and antiplatelet effects of Solidago chilensis Meyen rhizome aqueous extract and its derived fractions using in-vitro models. The antimicrobial analysis was performed against Staphylococcus aureus (ATCC 25922), Escherichia coli (ATCC 25923) and Pseudomonas aeruginosa (ATCC 27853). The broth microdilution method was used to determine the minimal inhibitory concentration (MIC). The measurement of platelet aggregation was determined by turbidimetric methodology. Significant differences were determined by analysis of variance (ANOVA), Dunnett’s or Student’s t tests. Values of P < 0.05 were considered significant. Theaqueous extract and its derived fractions prevented the growth of all the three tested microbial species. Furthermore, these extracts also significantly inhibited platelet aggregation (% of inhibition: AE: 45.0±4.0%, BuOH: 29.6±3.1% to 13.8±2.6%, and AR: 41.7±4.2%). Solidago chilensis Meyen rhizomes demonstrated important antimicrobial and antiplatelet aggregation activities, which may underlie their beneficial effect on bacterial infection and atherothrombotic diseases. Key words: Antimicrobial effect, antiplatelet activity, Solidago chilensis Meyen