A Selective α1A-Adrenoceptor Antagonist Inhibits Detrusor Overactivity in a Rat Model of Benign Prostatic Hyperplasia

Abstract

These results suggest that an excessive response to sympathetic nerve stimulation, which is mainly mediated via alpha(1A)-adrenoceptor, in the hypertrophied prostate gives rise to detrusor overactivity. Furthermore, the alpha(1A)-adrenoceptor selective antagonist KMD-3213 would be suitable for improving irritative symptoms in patients with benign prostatic hyperplasia.