Enzymatic ADP‐ribosylation of benzotriazoles and related triazoles. Difference of glycosidation site between triazoles and indazoles

Abstract

Abstract Some benzotriazoles and related triazole were ADP‐ribosylated in the presence of NAD and NAD‐nucleo‐sidase to give corresponding dinucleotides. The site of ribosylation for these dinucleotides was found exclusively to be N‐1 on the basis of their uv and 15 N‐nmr spectra, contrasting with N‐2 for indazole dinucleotides. The origin of this difference in regiochemical specificity between the triazole and diazole systems is discussed.