Herpes simplex virus thymidine kinase and granulocyte macrophage colony-stimulating factor combination gene therapy in a murine CT26 cell colon cancer model

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

Sara M. Freeman, Camille N. Abboud, Katharine A. Whartenby et al. · PubMed · 1993 · 1.1K citations

Medicine, Cancer Biology, Oncology +10

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

Marc Mesnil, C. Piccoli, Gérard Tiraby et al. · Proceedings of the National Academy of Sciences · 1996 · 414 citations

Life Sciences, Cell Biology, Oncology +17

Characteristics of a Serially Transplanted Mouse Mammary Tumor and Its Tissue-Culture-Adapted Derivative

Sara Rockwell, Robert F. Kallman, Luis F. Fajardo · JNCI Journal of the National Cancer Institute · 1972 · 406 citations

Veterinary Medicine, Cell Biology, Oncology +17

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene.

Manuel Caruso, Yves Panís, Singh Gagandeep et al. · Proceedings of the National Academy of Sciences · 1993 · 376 citations

Medicine, Oncology, Pharmacology +17

In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial

James R. Herman, Howard L. Adler, Estuardo Aguilar-Córdova et al. · Human Gene Therapy · 1999 · 306 citations

Medicine, Oncology, Pharmacology +16