Clinical Effect of Glucocorticoids on Kaposi Sarcoma Related to the Acquired Immunodeficiency Syndrome (AIDS)

Abstract

Brief Reports1 June 1989Clinical Effect of Glucocorticoids on Kaposi Sarcoma Related to the Acquired Immunodeficiency Syndrome (AIDS)Parkash S. Gill, MD, Carmen Loureiro, MD, Marjorie Bernstein-Singer, MD, Mark U. Rarick, MD, Fred Sattler, MD, Alexandra M. Levine, MDParkash S. Gill, MD, Carmen Loureiro, MD, Marjorie Bernstein-Singer, MD, Mark U. Rarick, MD, Fred Sattler, MD, Alexandra M. Levine, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-11-937 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptKaposi sarcoma occurs in over 20% of patients with the acquired immunodeficiency syndrome (AIDS), predominantly among homosexual or bisexual men (1). The human immunodeficiency virus (HIV) that causes AIDS (2), does not directly cause AIDS-related Kaposi sarcoma, as shown by the absence of HIV-1 in tissues from Kaposi sarcoma lesions (3). Recent studies suggest, however, that HIV-I may indirectly play a significant role in the development of Kaposi sarcoma (4, 5). Although the exact mechanism of the development of Kaposi sarcoma remains unknown, treatment with corticosteroids has historically been associated with an increased incidence of Kaposi sarcoma in non-HIV—related disease...References1. Update: acquired immunodeficiency syndrome—United States. MMWR. 1986;33:757-60, 765-6. Google Scholar2. PopovicSarngadharanReadGallo MMER. Detection, isolation, and continuous production of cytopathic retrovirusus (HTLV-III) from patients with AIDS and pre-AIDS. Science. 1984;224:497-500. CrossrefMedlineGoogle Scholar3. Delli BoviDontiKnowles PED. Presence of chromosomal abnormalities and lack of AIDS retrovirus DNA sequences in AIDS-associated Kaposi's sarcoma. Cancer Res. 1986;46:6333-8. MedlineGoogle Scholar4. NakamuraSalahuddinBiberfeld SSP. Kaposi's sarcoma cells: long-term culture with growth factor(s) from human retrovirus-infected CD4 + T cells. Science. 1988;242:426-30. CrossrefMedlineGoogle Scholar5. SalahuddinNakamuraBiberfeld SSP. Antigenic properties of Kaposi's sarcoma-derived cells after long-term culture in vitro. Science. 1988;242:430-3. CrossrefMedlineGoogle Scholar6. HarwoodOsobaHofstader ADS. Kaposi's sarcoma in recipients of renal transplants. Am J Med. 1979;67:759-65. CrossrefMedlineGoogle Scholar7. GillKrailoSlater PML. Randomized trial of ABV (adrimycin, bleomycin, vincristine) vs A in advanced Kaposi's sarcoma [Abstract]. Proceedings ASCO. 1988;7:3. Google Scholar8. O'DonnellFormanLevine MSA. Cytarabine, cisplatin, and etoposide for refractory non-Hodgkin's lymphoma. Cancer Treat Rep. 1987;71:187-9. MedlineGoogle Scholar9. RealKrownKoziner FSB. Steroid-related development of Kaposi's sarcoma in a homosexual man with Burkitt's lymphoma. Am J Med. 1986;80:119-22. CrossrefMedlineGoogle Scholar10. SchulhaferGrossmanFaginBell EMGK. Steroid-induced Kaposi's sarcoma in a patient with pre-AIDS. Am J Med. 1987;82:313-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of Southern California School of Medicine and the Los Angeles-USC Medical Center, Los Angeles, California. For current author addresses, see end of text. 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Pluda, MD, Robert Yarchoan, MD, Elaine S. Jaffe, MD, Irwin M. Feuerstein, MD, Diane Solomon, MD, Seth M. Steinberg, PhD, Kathleen M. Wyvill, RN, Andrew Raubitschek, MD, David Katz, MD, Samuel Broder, MDAre Corticosteroids Beneficial as Adjunctive Therapy for Pneumocystis Pneumonia in AIDS?Joseph A. Kovacs, MD, Henry Masur, MDComplications of Corticosteroid Therapy in Patients with the Acquired Immunodeficiency Syndrome and Pneumocystis carinii PneumoniaAcute myositis in a patient with the acquired immunodeficiency syndromeCorticotrophins and corticosteroids 1 June 1989Volume 110, Issue 11Page: 937-940KeywordsAIDSBisexualsHIVHIV-1HomosexualsKaposi sarcomaLesions Issue Published: 1 June 1989 PDF downloadLoading ...