A NEW APPLICATION OF INORGANIC CLUSTER, CARBORANES FOR MEDICINAL DRUG DESIGN AND MOLECULAR CONSTRUCTION

Abstract

The inorganic cage compounds, dicarba-closo-dodecaboranes (carboranes), are chemical building blocks of remarkable thermal and chemical stability, with spherical geometry and exceptional hydrophobic character. We have focused on medicinal drug design using carboranes as a hydrophobic pharmacophore and have developed a potent estrogen agonist, BE120. We also have applied carboranes for structural chemistry, utilizing their specific three-dimensional character to obtain multilayer aromatic structures.