Left Ventricular Dysfunction and Remodeling in Streptozotocin-Induced Diabetic Rats

Abstract

Advanced insulin-dependent DM incurred not only RV remodeling but also overt resting LV systolic dysfunction and decreased LV responsiveness to beta adrenergic stimulation with dilatational remodeling, accompanied by pathological changes of capillaries and cardiomyocytes including actin filaments.