Direct Organocatalytic Enantioselective Mannich Reactions of Ketimines: An Approach to Optically Active Quaternary α‐Amino Acid Derivatives

Abstract

You're in control of which diastereomer of a quaternary α-amino acid derivative is formed in a direct organocatalytic diastereoselective and enantioselective Mannich reaction of ketimines with aldehydes (see scheme). The reactions are high yielding and can be controlled through the choice of the catalyst to give either diastereomer of the product with diastereomeric ratios as high as >20:1 and with 83–98 % ee. Pg=protecting group. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460158_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.