Thioflavin Derivatives as Markers for Amyloid‐β Fibrils: Insights into Structural Features Important for High‐Affinity Binding

Abstract

How do we go together? Structural variations have been used to obtain information regarding the interaction of thioflavin-derived markers and amyloid-β fibril targets. Affinity variations of up to three orders of magnitude were observed, revealing some structural requirements for these markers at the molecular level.