Selective Pharmacologic Inhibition of c-Jun NH <sub>2</sub> -Terminal Kinase Radiosensitizes Thyroid Anaplastic Cancer Cell Lines via Induction of Terminal Growth Arrest - Concepedia

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Selective Pharmacologic Inhibition of c-Jun NH <sub>2</sub> -Terminal Kinase Radiosensitizes Thyroid Anaplastic Cancer Cell Lines via Induction of Terminal Growth Arrest

13

Citations

35

References

2006

Year

Dmitry Bulgin, Alexei Podtcheko, Shu Takakura, Norisato Mitsutake, Hiroyuki Namba, Vladimir Saenko, Akira Ohtsuru, Tatiana Rogounovitch, Iryna Palona, Shunichi Yamashita

Abstract

JNK signaling is an essential component of ATC cell proliferation and survival after radiation therapy. Hence, pharmacological interference with JNK pathway in combination with radiotherapy may be a promising treatment of ATC.

References

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