Fentanyl increases dopamine release in rat nucleus accumbens: involvement of mesolimbic mu- and delta-2-opioid receptors

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Psychopharmacology, Pharmacotherapy, Synaptic Dopamine Concentrations +18

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

Mary C. Ritz, R. J. Lamb, Steven R. Goldberg et al. · Science · 1987 · 2.2K citations

Dopamine Transporters, Substance Abuse, Psychoactive Drug +14

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

Rainer Spanagel, A. Herz, Toni S. Shippenberg · Proceedings of the National Academy of Sciences · 1992 · 1K citations · Full text

Mesolimbic Dopaminergic Pathway, Neurotransmitter, Dopamine Release +16

Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain

Alfred Mansour, Henry Khachaturian, M. E. Suzanne Lewis et al. · Pain · 1988 · 980 citations

Precise Localization, Pain Medicine, Pharmacotherapy +23

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.

G. Di Chiara, Assunta Impérato · Journal of Pharmacology and Experimental Therapeutics · 1988 · 921 citations