The Journal of Clinical Endocrinology & Metabolism · 1963 · 47 citations · 0 references
Life SciencesBiochemistryEndocrinologyHormone BiochemistryNeuroendocrinologySteroid BiochemistryAdrenal EndocrinologyAdrenal HormonesAdrenal Steroid HormonesAdrenal SteroidogenesisSteroid Hormone BiochemistrySteroid MetabolismAdrenal AndrogensSpecific Activity DeterminationSteroid GlucuronidationSteroid Sulfate MetabolismSulfate ChemistryUrinary Steroid Analysis
The isolation of dehydroisoandrosterone glucuronoside from normal human urine is described. When dehydroisoandrosterone was isolated from the urinary glucuronoside fraction after the administration of tritiated ehydroisoandrosterone, its specific activity was much larger than that of dehydroisoandrosterone isolated from the sulfate fraction. This indicates that the urinary sulfate is derived not only from dehydroisoandrosterone but also from the sulfate itself, which appears to be secreted by the adrenals.