Artefactual Nanoparticle Activation of the Inflammasome Platform: <i>in Vitro</i> Evidence with a Nano-Formed Calcium Phosphate

Abstract

In vitro studies often predict that engineered nanoparticles, such as synthetic apatite, are candidates for inflammasome activation and, hence, are toxic. However, the experimental setting must be very carefully considered as it may promote false-positive outcomes.