Neurology · 1991 · 511 citations · 0 references
NeuropsychologySpeech KinematicsNeurolinguisticsHemispheric Language DominanceSpeech ArrestMotor ControlSocial SciencesStimulation DeviceCognitive ElectrophysiologyNeurologySpeech Motor ControlHealth SciencesTranscranial StimulationSensorimotor IntegrationRehabilitationNeurostimulationBrain StimulationCounting ErrorsBrain-computer InterfaceMotor SpeechNeuroscienceSpeech PerceptionReproducible Speech Arrest
Six adult epileptic patients received 10‑second trains of rapid‑rate (up to 25 Hz) transcranial magnetic stimulation with an 11‑cm water‑cooled round coil positioned over 15 scalp sites on each hemisphere while they counted aloud. Stimulation over left D5 or D7 produced speech arrest in all patients and counting errors in three at lower intensities, with no disturbances on the right side, and the lateralization of these effects correlated with intracarotid amobarbital test results, suggesting rTMS could noninvasively determine hemispheric language dominance.
Six adult epileptic patients underwent rapid-rate transcranial magnetic stimulation (rTMS) at stimulation rates of up to 25 Hz with an 11-cm water-cooled round coil held flat on the scalp, centered over 15 different positions on each side of the scalp. The trains of stimuli were for 10 seconds while the patients counted aloud. rTMS centered over D5 or D7 induced reproducible speech arrest in all patients and counting errors in three when applied at lower intensities. There were no such speech disturbances by rTMS centered over the different positions on the right side. Intracarotid amobarbital test (IAT) demonstrated left hemispheric language dominance in all patients. Lateralization of speech arrest induced by rTMS correlated with the IAT results and may be helpful for noninvasive determination of hemispheric language dominance.