Journal of Applied Toxicology · 1987 · 13 citations · 4 references
PharmacyClinical ToxicologyToxicologyEnvironmental HealthEnvironmental ToxicologyToxicodynamicsBehavioral ToxicologyRespiratory MedicineRespiratory PathophysiologyRespiratory ToxicologyRodent ToxicologyInhalation Toxicity Of SolventsInhaled Chemical ToxicantsMechanical IrritationPhysical ExposuresRespiratory Depression AssessmentRespiratory Depression RiskRespiratory ResponseVapor Toxicity
The respiratory-depression (RD) profile in mice exposed to methylisocyanate (MIC) vapor is reported. The RD50 value calculated from this profile was 2.9 (2.7-3.2) ppm. Concentrations of MIC that have been reported to be unbearable in humans were of approximately the same magnitude as RD50 concentrations in mice for brief exposures.
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