Progestins and Skeletal Maturation

Abstract

THE association of virilization of the female fetus with the administration of certain progestins during pregnancy is now well recognized. Since Wilkins et al.1 first called attention to this matter other reports have appeared and have incriminated, although rarely, some estrogenic compounds as well.2 This brief report concerns 6 infants referred to this service because of masculinization of the genitalia. In addition to these changes 5 of the 6 patients were found to have significant advancement of bone maturation.Six female infants, four days to thirty months of age, with varying degrees of clitoral enlargement and labioscrotal fusion due to . . .