Coumestrol treatment prevents Na⁺, K⁺-ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia

Abstract

Coumestrol treatment was effective in preventing neuronal loss in all times of administration as well as able to rescue the Na+, K+ -ATPase activity, suggesting its potential benefits for either prevention or therapeutics use against cerebral ischemia in males.