1-Substituted 3-Dimethylaminoprop-2-en-1-ones as Building Blocks in Heterocyclic Synthesis: Routes to 6-Aryl- and 6-Heteroaryl-2H-pyran-2-ones and 6- and 4-Arylpyridin-2(1H)-ones

Abstract

Several new 6-substituted-3-acylamino-2H-pyran-2-ones 6a–j have been prepared from the reaction of enaminones 4a–f with N-acyl- and N-benzoyl-glycines; the enaminones 4a–c react with malononitrile in ethanol solution and in the presence of a base to yield amides 11a–c which are converted into 6-aryl-1,2-dihydro-2-oxypyridine-3-carbonitriles 13a–c on reflux in acetic acid.