Repeated Cycles of Binge‐Like Ethanol (<scp>E</scp>t<scp>OH</scp>)‐Drinking in Male<scp>C</scp>57<scp>BL</scp>/6<scp>J</scp>Mice Augments Subsequent Voluntary<scp>E</scp>t<scp>OH</scp>Intake But Not Other Dependence‐Like Phenotypes

Abstract

Excessive EtOH drinking stemming from DID procedures does not initially induce phenotypes consistent with a dependence-like state. However, the subsequent increases in voluntary EtOH consumption and preference that become more robust following repeated episodes of binge-like EtOH drinking may reflect the early stages of EtOH dependence, suggesting that DID procedures may be ideal for studying the transition to EtOH dependence.