Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Craig L. Bennett, Jacinda R. Christie, Fred Ramsdell et al. · Nature Genetics · 2001 · 3.4K citations

Life Sciences, Genetics, Immunology +13

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

Robert S. Wildin, Fred Ramsdell, Jane Peake et al. · Nature Genetics · 2001 · 1.9K citations

Medicine, Endocrinology, Pediatrics +17

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

Valérie Dardalhon, Amit Awasthi, Hyoung Kwon et al. · Nature Immunology · 2008 · 1.1K citations · Full text

Life Sciences, Immunology, Cellular Immunology +9

Linkage Analysis of <i>IL4</i> and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

David G. Marsh, John D. Neely, Daniel R. Breazeale et al. · Science · 1994 · 1K citations

Life Sciences, Genetics, Immunology +14

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

Talal A. Chatila, Frank Blaeser, Nga Ho et al. · Journal of Clinical Investigation · 2000 · 931 citations · Full text

Life Sciences, Genetics, Immunology +17